{"product_id":"the-polymerase-chain-reaction-volume-0","title":"The Polymerase Chain Reaction (Volume 0)","description":"James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases. \"It has not escaped our notice,\" Francis wrote, \"that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material.\" By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two chains that are complementary to each other. Each chain could then act \". . . as a template for the formation on itself of a new companion chain, so that eventually we shall have two pairs of chains, where we only had one before\" and, moreover, \" ...\u003cbr\u003eASIN: 0817637508\u003cbr\u003eVSKU: LFV.0817637508.A\u003cbr\u003eCondition: Acceptable\u003cbr\u003eAuthor\/Artist:Mullis, Kary B.|Watson, J.D.|Gibbs, Richard A.|Ferre, Francois\u003cbr\u003eBinding: Paperback\u003cbr\u003e\u003cb\u003eNote:\u003c\/b\u003e Any images shown are stock photographs and product may differ from what is shown.  \u003cbr\u003e\u003cb\u003eCondition Notes\u003c\/b\u003e: Book is in acceptable condition.  May have shelf wear, edge wear, and spine wear, but a very readable copy.  May not come with supplemental materials if applicable.  Does not include original dustcover jacket.  Possibly Ex Library Copy  \u003cbr\u003e","brand":"Books for Life","offers":[{"title":"Default Title","offer_id":46868033634501,"sku":"LFV.0817637508.A","price":14.66,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0650\/2914\/4773\/files\/0817637508-0.jpg?v=1788628444","url":"https:\/\/www.booksforlife.store\/products\/the-polymerase-chain-reaction-volume-0","provider":"Books for Life","version":"1.0","type":"link"}